Today, Dr. Lewis talked to us about my mom’s cytogenetics results. I will try to describe this in a accurate way, but please keep in mind that my road to learning the language of Cancer is still relatively new. I also need to brush up on some high school and college biology classes!
She has abnormalities in Chromosome 11. The results say:
Abnormal female karyotype with a deletion in the q-arm* of chromosome 11 in 4/5 metaphase cells available analyzed.
These abnormal cells also had additional non-clonal abnormalities.
The remaining 1/5 cell showed a 46,XX karyotype.
Submission of a follow-up specimen to monitor karyotypic evolution should be considered as clinically indicated. Karyotypic evolution often precedes disease progression.
*I read that q-arm = long-arm
This basically means that she is high risk. The abnormalities of Chromosome 11 affects the Mixed Lineage Leukemia (MLL) gene. The possibility of a stem-cell transplant is quite high at the moment. There is much to learn about cytogenetics and I will be updating this post as I learn more.
I found this article about Chromosome 11 and MLL.